Description

(4S)-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-3-(4-Hydroxybenzene) Propanoic Acid, Methyl Ester (Landiolol) is a high-purity chemical intermediate of significant importance in modern pharmaceutical synthesis. This compound serves as a critical building block for the production of Landiolol, an ultra-short-acting, cardioselective β-1 adrenergic receptor blocker used in clinical settings. It is essential for manufacturers in the active pharmaceutical ingredient (API) sector who require reliable, high-quality intermediates for complex synthesis routes. Our supply ensures consistent purity and stability, supporting robust and scalable pharmaceutical manufacturing processes.

Application

• Pharmaceutical Intermediate: Primary use as a key chiral synthon in the commercial synthesis of the API Landiolol hydrochloride.
• Cardiovascular Drug Research: Used in R&D for developing and studying new ultra-short-acting β-blockers and related cardiovascular agents.
• Process Chemistry Development: Employed in optimizing and scaling up synthetic pathways for β-adrenergic antagonists in pilot plants and production facilities.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing of Landiolol-based drug products.
• Chiral Building Block: Utilized in asymmetric synthesis for constructing other complex molecules requiring the (4S)-dioxolane moiety.

Basic Information

Product Name	(4S)-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-3-(4-Hydroxybenzene) Propanoic Acid, Methyl Ester (Landiolol)
CAS No.	144256-11-1
Molecular Formula	C16H22O5
Molecular Weight	294.34 g/mol
Synonyms	Landiolol Intermediate; (4S)-2,2-Dimethyl-1,3-dioxolane-4-propanoic acid, 3-(4-hydroxyphenyl)-, methyl ester; Methyl (4S)-3-(4-hydroxyphenyl)-2,2-dimethyl-1,3-dioxolane-4-propanoate; ONO-1101 Intermediate; (S)-Landiolol Precursor; 4S-Landiolol Ester; (S)-Methyl 3-(4-hydroxyphenyl)-2,2-dimethyl-1,3-dioxolane-4-propanoate
EINECS	Contact for details

Quality Control

Our (4S)-(2,2-Dimethyl-1,3-Dioxolan-4-Yl)-3-(4-Hydroxybenzene) Propanoic Acid, Methyl Ester is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing identity, assay, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.