Description

3-Amino-2,6-Difluorobenzonitrile is a high-purity, multi-functional aromatic building block characterized by its amino and cyano substituents on a difluorinated benzene ring. This unique structure makes it a critical intermediate for synthesizing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for creating novel active ingredients, as well as by fine chemical manufacturers producing specialty dyes and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, leveraging the fluorine atoms for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a building block for advanced polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing cyano group and potential for further functionalization.
• Dye and Pigment Manufacturing: Intermediate for producing specialized azo dyes and high-performance pigments where the amino group is essential for chromophore development.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) for creating complex biaryl and heteroaryl structures.

Basic Information

Product Name	3-Amino-2,6-Difluorobenzonitrile
CAS No.	143879-78-1
Molecular Formula	C7H4F2N2
Molecular Weight	154.12 g/mol
Synonyms	2,6-Difluoro-3-aminobenzonitrile; 3-Amino-2,6-difluorobenzonitrile; Benzonitrile, 3-amino-2,6-difluoro-; 2,6-Difluoro-3-cyanobenzeneamine; 3-Cyano-2,6-difluoroaniline; 2,6-Difluoro-3-aminobenzene carbonitrile
EINECS	Contact for details

Quality Control

Our production of 3-Amino-2,6-Difluorobenzonitrile adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for your synthetic processes. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.