Description

n-(4-Fluoro-2-Nitro-5-Trifluoromethylphenyl)-Acetamide is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl and nitro-substituted aromatic structure. This compound is of significant commercial importance for its role in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring fluorinated molecules. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing novel compounds with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of fluorinated drug candidates, including potential kinase inhibitors and anti-cancer agents.
• Agrochemical Research: Used in the development of new herbicides and pesticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science: Serves as a precursor for specialty chemicals and functional materials, such as liquid crystals or organic electronic components.
• Organic Synthesis: Employed in academic and industrial R&D for constructing complex aromatic systems via further functionalization of the nitro and acetamide groups.

Basic Information

Product Name	n-(4-Fluoro-2-Nitro-5-Trifluoromethylphenyl)-Acetamide
CAS No.	143151-01-3
Molecular Formula	C9H6F4N2O3
Molecular Weight	266.15 g/mol
Synonyms	N-[4-Fluoro-2-nitro-5-(trifluoromethyl)phenyl]acetamide; 2'-Nitro-4'-fluoro-5'-(trifluoromethyl)acetanilide; 4-Fluoro-2-nitro-5-trifluoromethylacetanilide; Acetamide, N-[4-fluoro-2-nitro-5-(trifluoromethyl)phenyl]-; 143151-01-3; 4-Fluoro-2-nitro-α,α,α-trifluoro-p-acetotoluidide
EINECS	Contact for details

Quality Control

Our n-(4-Fluoro-2-Nitro-5-Trifluoromethylphenyl)-Acetamide is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.