Description

Benzeneacetonitrile, 3-Fluoro-α-Hydroxy- (9Ci) CAS NO 143103-67-7 is a fluorinated aromatic nitrile derivative characterized by a hydroxyl group on the alpha carbon. This compound is a versatile and valuable pharmaceutical intermediate and building block in advanced organic synthesis. It is primarily utilized by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for the construction of complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides where the fluorine atom enhances biological activity and stability.
• Liquid Crystal & OLED Material Research: Used in the development of fluorinated organic electronic materials for displays and lighting applications.
• Advanced Organic Synthesis: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and in constructing complex molecular architectures.
• Chemical Research & Development: A valuable reagent for exploring new fluorination methodologies and reaction pathways in academic and industrial labs.

Basic Information

Product Name	Benzeneacetonitrile, 3-Fluoro-α-Hydroxy- (9Ci)
CAS No.	143103-67-7
Molecular Formula	C8H6FNO
Molecular Weight	151.14 g/mol
Synonyms	3-Fluoro-2-hydroxy-2-phenylacetonitrile; 2-Hydroxy-2-(3-fluorophenyl)acetonitrile; α-Hydroxy-3-fluorobenzeneacetonitrile; (3-Fluorophenyl)(hydroxy)acetonitrile; 3-Fluoro-mandelonitrile; 3-Fluorobenzaldehyde cyanohydrin
EINECS	Contact for details

Quality Control

Our Benzeneacetonitrile, 3-Fluoro-α-Hydroxy- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistent performance as a critical synthetic intermediate. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.