Description

(1R,2S)-Fluorocyclopropylamine Tosylate is a high-purity, chiral fluorinated building block of significant importance in modern pharmaceutical and agrochemical research. Its unique cyclopropylamine scaffold, combined with fluorine substitution, is critical for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of novel active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of antiviral, antibacterial, and central nervous system (CNS) active drugs.
• Agrochemical Synthesis: Used in creating novel pesticides and herbicides where the fluorocyclopropyl group enhances bioactivity and environmental stability.
• Peptidomimetics & Bioisosteres: Serves as a rigid, fluorine-containing scaffold to replace peptide bonds or other functional groups in drug design.
• Ligand & Catalyst Development: Employed in the synthesis of chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and biological pathways.
• Process Chemistry: Serves as a critical starting material in the scale-up and optimization of synthetic routes for commercial API manufacturing.

Basic Information

Product Name	(1R,2S)-Fluorocyclopropylamine Tosylate
CAS No.	143062-73-1
Molecular Formula	C11H16FNO3S
Molecular Weight	261.31 g/mol
Synonyms	(1R,2S)-1-Amino-2-fluorocyclopropane p-toluenesulfonate; (1R,2S)-2-Fluorocyclopropanamine 4-methylbenzenesulfonate; trans-1-Amino-2-fluorocyclopropane Tosylate; (1R,2S)-1-Fluoro-2-aminocyclopropane Tosylate; Fluorocyclopropylamine Tosylate (enantiomer); FCAT; (1R,2S)-FCAT; (1R,2S)-F-CPr-NH2·TsOH
EINECS	Contact for details

Quality Control

Our (1R,2S)-Fluorocyclopropylamine Tosylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess (ee), and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.