Description

(-)-Homochlorcyclizine CAS NO 142860-97-7 is a specific enantiomer of the antihistamine compound homochlorcyclizine, characterized by its high stereochemical purity. This compound is of significant value in pharmaceutical research and development, particularly for studying structure-activity relationships and receptor binding specificity. It is primarily needed by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions focused on developing or analyzing new therapeutic agents, especially in the fields of allergy, inflammation, and central nervous system (CNS) research.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and scale-up of enantiomerically pure pharmaceutical compounds.
• Pharmacological Research: Critical for preclinical studies investigating the differential effects of enantiomers on histamine H1-receptor activity.
• Analytical Chemistry: Employed as a standard in chromatographic methods (e.g., HPLC, Chiral HPLC) for assay development and impurity profiling.
• Academic & Institutional R&D: Utilized in university and institutional labs for fundamental research in medicinal chemistry and pharmacology.
• Regulatory Submissions: Provides essential data for drug master files (DMFs) and regulatory documentation requiring characterization of stereoisomers.

Basic Information

Product Name	(-)-Homochlorcyclizine
CAS No.	142860-97-7
Molecular Formula	C19H23ClN2
Molecular Weight	314.86 g/mol
Synonyms	(-)-Homochlorcyclizine; (S)-Homochlorcyclizine; Levohomochlorcyclizine; 1-[(4-Chlorophenyl)phenylmethyl]-4-methylpiperazine, (S)-; Homochlorcyclizine (-)-enantiomer; L-Homochlorcyclizine; Homochlorcyclizine S-isomer; Homochlorcyclizine levo form
EINECS	Contact for details

Quality Control

Our (-)-Homochlorcyclizine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and enantiomeric excess meet high standards suitable for research and development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from tests including chiral purity assay, related substances, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.