Description

(+)-Homochlorcyclizine CAS NO 142860-96-6 is a high-purity, single-enantiomer form of the antihistaminic compound homochlorcyclizine. This specific stereoisomer is of significant interest in advanced pharmaceutical research and development due to its potential for enhanced biological activity and selectivity. It serves as a critical chiral building block and reference standard for scientists in medicinal chemistry and pharmacology. Target users include pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• As a chiral reference standard for analytical method development and validation in pharmaceutical quality control.
• Utilized as a key pharmacological research tool for studying histamine H1-receptor interactions and structure-activity relationships (SAR).
• Serving as a high-value chemical intermediate in the synthesis of novel therapeutic agents and specialized fine chemicals.
• Application in preclinical studies to investigate the efficacy and metabolic profile of the specific enantiomer.
• Use in asymmetric synthesis research to develop new catalytic pathways for chiral molecule production.
• Potential use in the development of diagnostic kits or assays requiring enantiomerically pure components.

Basic Information

Product Name	(+)-Homochlorcyclizine
CAS No.	142860-96-6
Molecular Formula	C18H21ClN2
Molecular Weight	300.83 g/mol
Synonyms	(+)-1-[(4-Chlorophenyl)(phenyl)methyl]-4-methylpiperazine; (R)-Homochlorcyclizine; Dextro-Homochlorcyclizine; (+)-Homochlorcyclizine Dihydrochloride (salt form); NSC 113001; Homochlorcyclizine enantiomer; (R)-1-(p-Chlorobenzhydryl)-4-methylpiperazine
EINECS	Contact for details

Quality Control

Our (+)-Homochlorcyclizine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. We provide full traceability and support our products with detailed Certificates of Analysis (COA). Specifications are aligned with the needs of research and development, and we can support compliance with relevant pharmacopeial standards (e.g., USP, EP) for reference materials upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.