Description

1-(tert-Butoxy)-4-Fluoro-2-Nitrobenzene is a high-purity, specialized aromatic compound featuring a tert-butoxy group, a fluorine atom, and a nitro substituent on the benzene ring. This unique structure makes it a valuable and versatile building block in advanced organic synthesis, particularly for the development of complex molecules. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine and nitro groups contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and organic pigments due to its electron-withdrawing nitro group and potential for further functionalization.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct biaryl and other complex molecular architectures.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating compound libraries for screening in drug discovery programs.

Basic Information

Product Name	1-(tert-Butoxy)-4-Fluoro-2-Nitrobenzene
CAS No.	142596-59-6
Molecular Formula	C10H12FNO3
Molecular Weight	213.21 g/mol
Synonyms	4-Fluoro-2-nitro-1-(tert-butoxy)benzene; 1-tert-Butoxy-4-fluoro-2-nitrobenzene; 2-Nitro-4-fluoro-1-(tert-butoxy)benzene; Benzene, 1-(1,1-dimethylethoxy)-4-fluoro-2-nitro-; 4-Fluoro-2-nitro-1-(1,1-dimethylethoxy)benzene; 1-(tert-Butyloxy)-4-fluoro-2-nitrobenzene; 4-Fluoro-2-nitro-1-(tert-butyloxy)benzene; 1-(tert-Butoxy)-4-fluoro-2-nitro-benzene
EINECS	Contact for details

Quality Control

Our 1-(tert-Butoxy)-4-Fluoro-2-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by HPLC or GC), and impurity profiles is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.