Description

2-Hydroxy-5-Trifluoromethylbenzonitrile is a versatile fluorinated aromatic nitrile building block, prized for its unique trifluoromethyl and phenolic hydroxyl substituents. This compound is critical for introducing lipophilicity and metabolic stability into advanced molecular architectures. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors, anti-inflammatory agents, and CNS drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group enhances biological activity.
• Material Science: Serves as a monomer or precursor for specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Research: Employed in organic synthesis as a versatile building block for constructing complex fluorinated heterocycles and other fine chemicals.
• Dye & Pigment Industry: Acts as an intermediate in the synthesis of specialized fluorinated dyes and pigments.

Basic Information

Product Name	2-Hydroxy-5-Trifluoromethylbenzonitrile
CAS No.	142167-36-0
Molecular Formula	C8H4F3NO
Molecular Weight	187.12 g/mol
Synonyms	5-(Trifluoromethyl)-2-hydroxybenzonitrile; 2-Cyano-4-(trifluoromethyl)phenol; 4-Trifluoromethylsalicylonitrile; 2-Hydroxy-4-(trifluoromethyl)benzonitrile; 2-Hydroxy-α,α,α-trifluoro-p-toluonitrile; Salicylonitrile, 5-(trifluoromethyl)-; 5-Trifluoromethylsalicylonitrile; 5-Trifluoromethyl-2-hydroxybenzonitrile
EINECS	Contact for details

Quality Control

Our 2-Hydroxy-5-Trifluoromethylbenzonitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for all shipments to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.