Description

Adriamycinol is a significant metabolite of the widely used anthracycline chemotherapeutic agent, Doxorubicin (Adriamycin). This compound is of critical importance in pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the mechanisms of action and toxicity associated with anthracycline therapies. It serves as a vital reference standard and intermediate for researchers and manufacturers in the pharmaceutical, biotechnology, and academic research sectors who are developing new oncology treatments or conducting safety and efficacy studies.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for the quantitative and qualitative analysis of Doxorubicin and its metabolites in biological matrices and pharmaceutical formulations.
• Metabolite Research: Essential for studying the metabolic pathways, pharmacokinetics, and biodistribution of anthracycline drugs in preclinical and clinical research.
• Toxicity and Efficacy Studies: Employed in investigative studies to understand the role of specific metabolites in the therapeutic effects and dose-limiting cardiotoxicity of Doxorubicin.
• Analytical Method Development: Serves as a critical component in developing and validating analytical methods, such as HPLC, LC-MS, and immunoassays, for drug monitoring and impurity profiling.
• Chemical Intermediate: Can be utilized as a building block or precursor in the synthetic chemistry of novel anthracycline derivatives or prodrugs.

Basic Information

Item	Details
Product Name	Adriamycinol
CAS No.	141434-67-5
Molecular Formula	C27H29NO11
Molecular Weight	543.52 g/mol
Synonyms	Doxorubicinol; 13-Dihydrodoxorubicin; 13-Dihydro-14-hydroxydaunomycin; Adriamycin Metabolite; (7S,9S)-7-[(2R,4S,5S,6S)-4-Amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
EINECS	Contact for details

Quality Control

Our Adriamycinol is produced and handled under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity assessment by HPLC. A detailed Certificate of Analysis (COA), documenting purity, related substances, and other critical parameters, is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing desiccated at -20°C. Handle and store in accordance with safe laboratory practices for pharmaceutical compounds.

Specification

Item	Specification
Appearance	Red-orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.