Description

1,4-Difluoro-2-Methyl-5-Nitrobenzene is a high-purity fluorinated nitroaromatic compound serving as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of fluorine and nitro groups on the benzene ring, which enables precise modifications to create molecules with targeted properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the difluoro-methyl-nitrobenzene structure contributes to efficacy and environmental profile.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments, leveraging the nitro group for chromophore development.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing biaryl and complex heterocyclic systems.

Basic Information

Product Name	1,4-Difluoro-2-Methyl-5-Nitrobenzene
CAS No.	141412-60-4
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2-Methyl-1,4-difluoro-5-nitrobenzene; 1,4-Difluoro-2-methyl-5-nitrobenzene; 5-Nitro-1,3-difluoro-2-methylbenzene; 2,5-Difluoro-4-nitrotoluene; 4-Nitro-2,5-difluorotoluene; Benzene, 1,4-difluoro-2-methyl-5-nitro-; DFMNB
EINECS	Contact for details

Quality Control

Our 1,4-Difluoro-2-Methyl-5-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP or research purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.