Description

Mapinastine is a selective histamine H1 receptor antagonist with significant anti-allergic properties. This compound is a key intermediate in the research and development of novel pharmaceutical agents targeting allergic conditions and inflammatory responses. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers engaged in the synthesis of advanced therapeutic candidates. The material is supplied as a high-purity building block to support innovation in drug discovery pipelines.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced antihistamine and anti-allergic drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies of histamine H1 receptor activity and signal transduction pathways.
• Preclinical Development: Employed in the formulation and testing of new chemical entities (NCEs) for allergy and inflammation models.
• Fine Chemical Synthesis: Acts as a specialized precursor for custom synthesis and process development within contract manufacturing organizations (CMOs).
• Academic Research: Utilized in university and institutional labs for investigating the structure-activity relationships (SAR) of histamine receptor antagonists.

Basic Information

Product Name	Mapinastine
CAS No.	140945-32-0
Molecular Formula	C19H21N3O
Molecular Weight	307.39 g/mol
Synonyms	Mapinastine; 140945-32-0; 1-[(4-Fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine; UNII-3F9U2B2Y4M; 3F9U2B2Y4M; BRN 1250475; CHEMBL2103875; DTXSID6047660; 1-[(4-Fluorophenyl)methyl]-N-piperidin-4-yl-1H-benzimidazol-2-amine
EINECS	Contact for details

Quality Control

Our Mapinastine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.