Description

Galarubicin Hydrochloride is a synthetic anthracycline derivative of significant interest in pharmaceutical research and development. This compound is valued for its potential as a key intermediate or active pharmaceutical ingredient (API) in the creation of novel chemotherapeutic agents. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in oncology drug discovery and preclinical studies.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced anthracycline-based anticancer drugs.
• Oncology Research: Used as a reference standard or experimental compound in biochemical and pharmacological studies targeting DNA intercalation and topoisomerase II inhibition.
• API Development: Investigated for formulation into potential injectable chemotherapeutic agents in preclinical and clinical trial stages.
• Mechanistic Studies: Employed in laboratory research to understand the structure-activity relationships (SAR) of anthracycline derivatives.
• Bioconjugation: Potential use in the development of antibody-drug conjugates (ADCs) for targeted cancer therapy.

Basic Information

Product Name	Galarubicin Hydrochloride
CAS No.	140637-82-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Galarubicin HCl; 4'-O-Tetrahydropyranyladriamycin Hydrochloride; THP-Adriamycin Hydrochloride; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride; Pirarubicin Hydrochloride (Note: Pirarubicin is a closely related derivative; verify specific structure for Galarubicin); 4'-O-THP-Doxorubicin Hydrochloride
EINECS	Contact for details

Quality Control

Our Galarubicin Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of related substances and residual solvents. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.