Description

Di-2',8'-o-Di-5',5'-N,n-Methylstreptonigrone is a complex, semi-synthetic derivative of the potent antitumor antibiotic, streptonigrin. This compound is valued for its enhanced pharmacological profile and serves as a critical advanced intermediate in the research and development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology drug discovery and process development.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of next-generation anticancer drug candidates.
• Biochemical Research: Used as a reference standard and probe compound in studies of DNA intercalation and topoisomerase inhibition.
• Mechanism of Action Studies: Employed in preclinical research to investigate apoptosis pathways and cellular response to cytotoxic agents.
• Process Chemistry Development: Serves as a model compound for optimizing fermentation, isolation, and derivatization processes for complex natural product analogs.
• Library Synthesis: Used to generate focused libraries of streptonigrin derivatives for high-throughput screening against various cancer cell lines.

Basic Information

Product Name	Di-2',8'-o-Di-5',5'-N,n-Methylstreptonigrone
CAS No.	140458-71-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Methylstreptonigrone; Di-N,N'-Methylstreptonigrone derivative; Streptonigrin methyl derivative; Antibiotic MA 144 M1 derivative; 5,5'-N,N-Dimethylstreptonigrone; NSC-Derivative; ATCC Derivative
EINECS	Contact for details

Quality Control

Our Di-2',8'-o-Di-5',5'-N,n-Methylstreptonigrone is produced under a strict quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency suitable for research applications. Certificates of Analysis (COA) detailing purity (by HPLC), identity confirmation (by IR, NMR), and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Dark red to brown powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.