Description

(+)-S-Arotinolol CAS NO 139332-61-9 is the pharmacologically active S-enantiomer of arotinolol, a non-selective β-adrenergic receptor antagonist (β-blocker) with intrinsic sympathomimetic activity. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure cardiovascular pharmaceuticals. It is primarily utilized by pharmaceutical R&D laboratories, process chemists, and manufacturers specializing in advanced active pharmaceutical ingredients (APIs) for hypertension and angina pectoris treatment.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiopure arotinolol hydrochloride and related β-blocker APIs.
• Cardiovascular Drug Research: Reference standard and active material in preclinical and clinical studies for hypertension and angina.
• Chiral Catalyst & Ligand Development: Serves as a precursor or model compound for developing asymmetric synthesis methodologies.
• Metabolite Studies: Used in the identification and characterization of drug metabolites during pharmacokinetic research.
• Analytical Standard: High-purity material for HPLC, LC-MS, and chiral chromatography method development and validation.
• Formulation Development: Employed in stability testing and dosage form development for new drug applications (NDAs).

Basic Information

Product Name	(+)-S-Arotinolol
CAS No.	139332-61-9
Molecular Formula	C15H21N3O2S2
Molecular Weight	339.48 g/mol
Synonyms	(S)-Arotinolol; (S)-5-[2-[[3-(1,1-Dimethylethyl)amino]-2-hydroxypropyl]thio]-4-thiazolyl]-2-thiophenecarboxamide; (S)-Almarl; S-(-)-Arotinolol; UNII-9V78R8WQ4H; Arotinolol S-Enantiomer; (S)-Form Arotinolol; β-blocker S-Isomer
EINECS	Contact for details

Quality Control

Our (+)-S-Arotinolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet exacting standards for pharmaceutical development. We provide full traceability and Certificates of Analysis (COA) detailing results from HPLC, chiral analysis, NMR, and residual solvent testing. Our quality commitment aligns with ICH guidelines and cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.