Description

Benzonitrile, 2-Fluoro-3-Hydroxy-4-Methoxy- is a high-purity, multi-functional aromatic nitrile derivative distinguished by its unique substitution pattern. This compound serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis, enabling the introduction of fluorine and methoxy pharmacophores. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides, leveraging its fluorine moiety for enhanced biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and liquid crystals due to its polar nitrile group and aromatic core.
• Fluorine Chemistry Studies: An important substrate for investigating fluorination reactions and studying structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	Benzonitrile, 2-Fluoro-3-Hydroxy-4-Methoxy-
CAS No.	137747-50-3
Molecular Formula	C9H8FNO2
Molecular Weight	181.16 g/mol
Synonyms	2-Fluoro-3-hydroxy-4-methoxybenzonitrile; 4-Methoxy-2-fluoro-3-hydroxybenzonitrile; 3-Hydroxy-4-methoxy-2-fluorobenzonitrile; 2-Fluoro-3-hydroxy-4-methoxybenzenecarbonitrile; 2-Fluoro-3-hydroxy-p-anisonitrile; 137747-50-3; Fluorohydroxymethoxybenzonitrile
EINECS	Contact for details

Quality Control

Every batch of Benzonitrile, 2-Fluoro-3-Hydroxy-4-Methoxy- is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is light-sensitive and should be stored away from light. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.