Description

2-Fluoro-4-Iodobenzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both fluorine and iodine substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications such as cross-coupling reactions and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry for creating fluorinated and iodinated aromatic scaffolds.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, where the fluorine atom can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings to form biaryl structures.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Useful for synthesizing labeled compounds and probes for imaging and diagnostic applications.

Basic Information

Product Name	2-Fluoro-4-Iodobenzonitrile
CAS No.	137553-42-5
Molecular Formula	C7H3FIN
Molecular Weight	246.99 g/mol
Synonyms	4-Iodo-2-fluorobenzonitrile; 2-Fluoro-4-iodobenzonitrile; Benzonitrile, 2-fluoro-4-iodo-; 2-Fluoro-4-iodobenzene carbonitrile; 4-Cyano-3-fluoroiodobenzene; 2-Fluoro-4-iodophenyl cyanide; 4-Iodo-2-fluorophenyl cyanide; 137553-42-5
EINECS	Contact for details

Quality Control

Our 2-Fluoro-4-Iodobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, NMR, and IR is provided with every shipment to guarantee traceability and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.