Description

Pyrrolidine, 1-(2-Fluoro-3-Methyl-1-Oxopentyl)-2,5-Dimethyl-, [2S-[1(2R*,3R*),2Alpha,5Beta]]- (9Ci) is a high-purity, stereochemically defined fluorinated pyrrolidine derivative, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a complex, multi-functional scaffold that enables the precise construction of biologically active molecules with defined three-dimensional architecture. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients where fluorination and specific stereochemistry are key to modulating potency, metabolic stability, and selectivity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in therapeutic areas targeting the central nervous system, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the design and synthesis of advanced crop protection agents, where its fluorinated pyrrolidine structure can enhance bioactivity and environmental stability.
• Methodology Development: Serves as a sophisticated substrate in academic and industrial research for developing new asymmetric synthesis and fluorination methodologies.
• Ligand and Catalyst Precursor: Potential use in the synthesis of novel chiral ligands or organocatalysts for asymmetric catalysis.
• Chemical Biology Probe: Employed in the construction of molecular probes to study enzyme mechanisms or protein-ligand interactions due to its complex, drug-like structure.

Basic Information

Item	Details
Product Name	Pyrrolidine, 1-(2-Fluoro-3-Methyl-1-Oxopentyl)-2,5-Dimethyl-, [2S-[1(2R*,3R*),2Alpha,5Beta]]- (9Ci)
CAS No.	136734-71-9
Molecular Formula	C12H22FNO2
Molecular Weight	231.31 g/mol
Synonyms	1-(2-Fluoro-3-methyl-1-oxopentyl)-2,5-dimethylpyrrolidine; (2S,5S)-1-[(2R,3R)-2-Fluoro-3-methylpentanoyl]-2,5-dimethylpyrrolidine; 2,5-Dimethyl-1-(2-fluoro-3-methyl-1-oxopentyl)pyrrolidine; Fluorinated pyrrolidine ketone; Chiral fluorinated pyrrolidine derivative; (2S,5S)-2,5-Dimethyl-1-((2R,3R)-2-fluoro-3-methylpentanoyl)pyrrolidine
EINECS	Contact for details

Quality Control

Every batch of our Pyrrolidine, 1-(2-Fluoro-3-Methyl-1-Oxopentyl)-2,5-Dimethyl-, [2S-[1(2R*,3R*),2Alpha,5Beta]]- (9Ci) is manufactured under strict quality management systems and undergoes comprehensive analytical characterization to ensure identity, purity, and stereochemical integrity. Our rigorous quality testing includes chiral HPLC, NMR, and MS to confirm specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support compliance with relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.