Description

(S)-(+)-Dimethindene Maleate is the pharmacologically active enantiomer of the well-known antihistaminic agent, dimethindene. This high-purity chiral compound is critical for advanced pharmaceutical research and development, particularly in creating more targeted and efficacious therapeutic formulations with potentially reduced side-effect profiles. It is primarily sought by pharmaceutical manufacturers and R&D laboratories specializing in enantiomerically pure active pharmaceutical ingredients (APIs) for allergy and inflammation-related treatments.

Application

• As a key chiral intermediate or reference standard in the research and development of novel antihistamine drugs.
• For use as an enantiomerically pure Active Pharmaceutical Ingredient (API) in the formulation of advanced, single-isomer pharmaceutical products.
• In pharmacological studies investigating the specific activity, metabolism, and receptor binding of the (S)-enantiomer compared to the racemic mixture.
• As a critical raw material for the synthesis of more complex, chirally-defined pharmaceutical compounds.
• For analytical purposes, serving as a high-purity standard in HPLC, LC-MS, or other chromatographic methods for quality control and method development.
• In academic and industrial research focused on chiral separation technologies and asymmetric synthesis.

Basic Information

Product Name	(S)-(+)-Dimethindene Maleate
CAS No.	136152-65-3
Molecular Formula	C20H24N2 • C4H4O4
Molecular Weight	408.47 g/mol
Synonyms	(S)-(+)-Dimethindene Maleate; (+)-(S)-Dimethindene Maleate; (S)-Dimethindene Maleate; (S)-1-[2-[1-(4-tert-Butylphenyl)ethyl]-3-indenyl]ethyl]pyridine Maleate; Forhistal (enantiomer); Fenistil (enantiomer); Dimethindene (S)-(+)-isomer Maleate; (S)- enantiomer of Dimethindene Maleate
EINECS	Contact for details

Quality Control

Our (S)-(+)-Dimethindene Maleate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. We provide full traceability and support our products with detailed Certificates of Analysis (COA), which include results for assay, chiral purity (HPLC), residual solvents, and related substances. Our quality standards are designed to support cGMP-compliant pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.