Description

4-Chloro-2,5-Difluorobenzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant commercial importance. Its unique structure, featuring both chloro and fluoro substituents on the benzonitrile core, makes it a versatile intermediate for synthesizing advanced materials and active pharmaceutical ingredients (APIs). This compound is essential for R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific halogenated motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the difluoro and chloro groups enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Polymer Chemistry: Acts as a monomer or modifying agent for engineering plastics and high-performance polymers.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and electron-transport materials.
• Chemical Research & Development: A valuable building block for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) in medicinal and process chemistry.

Basic Information

Product Name	4-Chloro-2,5-Difluorobenzonitrile
CAS No.	135748-35-5
Molecular Formula	C7H2ClF2N
Molecular Weight	173.55 g/mol
Synonyms	2,5-Difluoro-4-chlorobenzonitrile; 4-Chloro-2,5-difluorobenzene carbonitrile; 1-Chloro-2,5-difluoro-4-cyanobenzene; Benzonitrile, 4-chloro-2,5-difluoro-; 4-Chloro-2,5-difluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,5-Difluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistent quality suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.