Description

2-Chloro-4,5-Difluorobenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring chlorine and fluorine substituents on the benzonitrile core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the difluoro and chloro groups contribute to biological activity.
• Liquid Crystal & OLED Materials: Used in the research and production of specialty chemicals for electronic displays, leveraging its aromatic and halogenated structure to modify electronic properties.
• Polymer & Resin Modifiers: Acts as a monomer or cross-linking agent in the synthesis of high-performance polymers, imparting specific chemical resistance and thermal stability.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce functionalized aromatic rings into complex molecular architectures.

Basic Information

Product Name	2-Chloro-4,5-Difluorobenzonitrile
CAS No.	135748-34-4
Molecular Formula	C7H2ClF2N
Molecular Weight	173.55 g/mol
Synonyms	2-Chloro-4,5-difluorobenzonitrile; 4,5-Difluoro-2-chlorobenzonitrile; Benzonitrile, 2-chloro-4,5-difluoro-; 2-Chloro-4,5-difluorophenyl cyanide; 135748-34-4; 2-Cl-4,5-F2-Ph-CN
EINECS	Contact for details

Quality Control

Our 2-Chloro-4,5-Difluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.