Description

(-)-Bevantolol CAS NO 135531-41-8 is a high-purity, single-enantiomer pharmaceutical intermediate and research chemical belonging to the class of β-adrenergic blocking agents. This compound is critical for the development and production of enantiomerically pure cardiovascular drugs, where the specific stereochemistry is essential for targeted biological activity and reduced side-effect profiles. It is primarily utilized by pharmaceutical R&D laboratories, API (Active Pharmaceutical Ingredient) manufacturers, and academic institutions engaged in cardiovascular and receptor pharmacology studies.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of enantiomerically pure β-blocker APIs.
• Research & Development: Used as a reference standard and pharmacological tool in cardiovascular and adrenergic receptor research.
• Active Pharmaceutical Ingredient (API) Synthesis: Integral component in multi-step synthetic routes for producing final drug substances.
• Metabolite Studies: Employed in the investigation of drug metabolism and pharmacokinetics (DMPK) for related therapeutic agents.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(-)-Bevantolol
CAS No.	135531-41-8
Molecular Formula	C20H25NO4
Molecular Weight	343.42 g/mol
Synonyms	(-)-Bevantolol; (2R)-1-{[3,4-Dimethoxyphenethyl]amino}-3-(3-methylphenoxy)propan-2-ol; Levobevantolol; (R)-Bevantolol; Bevantolol (S-enantiomer); CL 77555; L-Bevantolol; NCI 60_003529
EINECS	Contact for details

Quality Control

Our (-)-Bevantolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.