Description

(+)-Bevantolol CAS NO 135531-40-7 is the pharmacologically active enantiomer of Bevantolol, a selective β-1 adrenergic receptor antagonist. This high-purity chiral intermediate is critical for research and development in cardiovascular pharmacology, enabling precise study of stereospecific drug-receptor interactions. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for the development of novel β-blocker therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of enantiomerically pure β-blocker Active Pharmaceutical Ingredients (APIs).
• Cardiovascular Research: Used as a reference standard and tool compound in preclinical studies to investigate the mechanisms and efficacy of β-1 adrenergic receptor blockade.
• Analytical Standard: Employed in method development and validation for chromatographic assays (e.g., HPLC, Chiral HPLC) to quantify enantiomeric purity in drug substances.
• Metabolite Studies: Utilized in pharmacokinetic and metabolic pathway research to understand the disposition of the active enantiomer.
• Process Chemistry: Acts as a critical intermediate in the development and scale-up of stereoselective synthetic routes for pharmaceutical manufacturing.

Basic Information

Product Name	(+)-Bevantolol
CAS No.	135531-40-7
Molecular Formula	C20H27NO4
Molecular Weight	345.44 g/mol
Synonyms	(+)-Bevantolol; (R)-Bevantolol; Bevantolol enantiomer; 1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)-2-propanol (R)-; Bevantolol (R)-form; CL 77577; NCR 77577; (2R)-1-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-methylphenoxy)propan-2-ol
EINECS	Contact for details

Quality Control

Our (+)-Bevantolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet stringent specifications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for key parameters including assay, chiral purity by HPLC, and related substances. We support compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.