Description

Locoid C is a high-purity active pharmaceutical ingredient (API) primarily used in topical corticosteroid formulations. This compound is valued for its potent anti-inflammatory and immunosuppressive properties, making it a critical component in advanced dermatological treatments. It is essential for pharmaceutical manufacturers developing prescription-strength creams, ointments, and lotions for treating various inflammatory skin conditions such as eczema, psoriasis, and dermatitis.

Application

• Primary active ingredient in topical corticosteroid creams and ointments for prescription dermatological use.
• Formulation of anti-inflammatory and anti-pruritic medications for managing eczema (atopic dermatitis).
• Key component in treatments for psoriasis to reduce plaque formation and skin cell proliferation.
• Used in contact dermatitis and allergic skin reaction therapies.
• Incorporated into specialized lotions for treating seborrheic dermatitis and other scalp conditions.
• Base material for veterinary dermatological products for inflammatory skin disorders in animals.
• Used in clinical research and reference standard preparation for analytical testing.

Basic Information

Product Name	Locoid C
CAS No.	135467-84-4
Molecular Formula	C24H32FO5
Molecular Weight	428.51 g/mol
Synonyms	Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone butyrate propionate; Pivalone; Locoidon; Locoid Crelo; (11β)-21-(1-Oxopropoxy)-17-[(1-oxobutoxy)]-11-hydroxy-4-pregnene-3,20-dione; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 17-butyrate 21-propionate
EINECS	Contact for details

Quality Control

Our Locoid C is manufactured under strict quality management systems, targeting compliance with ICH Q7 guidelines for active pharmaceutical ingredients. Every batch undergoes comprehensive analytical testing including HPLC for assay and impurity profiling, residual solvent analysis (GC), and microbiological testing. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and adherence to specified purity criteria.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after each use to prevent moisture absorption, which can affect stability and potency. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 1.0%
Related Substances (HPLC)	Total impurities: NMT 2.0% Any individual impurity: NMT 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	NMT 20 ppm
Microbial Limit	Complies with Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.