Description

(2,2-Difluorobenzo[D][1,3]Dioxol-5-Yl)Methanamine is a high-purity, fluorinated heterocyclic amine building block of significant interest in advanced organic synthesis. Its unique difluoromethylenedioxy (difluoro-1,3-benzodioxole) scaffold makes it a valuable precursor for developing novel active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can improve lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials with specific electronic or optical properties.
• Fluorine Chemistry Building Block: An essential starting material for introducing the difluoromethylenedioxy moiety into more complex molecular architectures.
• Custom Synthesis and Contract Manufacturing: Supplied to CROs and CDMOs for client-specific research projects and scale-up campaigns.

Basic Information

Item	Details
Product Name	(2,2-Difluorobenzo[D][1,3]Dioxol-5-Yl)Methanamine
CAS No.	135132-35-3
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	5-(Aminomethyl)-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-1,3-benzodioxole-5-methanamine; 5-(Aminomethyl)-2,2-difluorobenzo[d][1,3]dioxole; 2,2-Difluorobenzo[1,3]dioxol-5-ylmethanamine; (2,2-Difluoro-1,3-benzodioxol-5-yl)methylamine; 135132-35-3; (2,2-Difluorobenzo[d][1,3]dioxol-5-yl)methanamine
EINECS	Contact for details

Quality Control

Our (2,2-Difluorobenzo[D][1,3]Dioxol-5-Yl)Methanamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.