Description

3,4,5-Trifluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block essential for advanced organic synthesis. This compound is valued for its trifluoromethyl-substituted benzene ring, which imparts unique electronic and steric properties critical for modulating the activity of target molecules. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as in materials science for developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and CNS-targeted drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays.
• Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymers, improving their chemical resistance and thermal stability.
• Organic Electronics: Acts as a building block for electron-transport materials and semiconductors in OLEDs and organic photovoltaics.
• Chemical Research: A versatile reagent for Suzuki, Sonogashira, and other cross-coupling reactions to create complex, multi-substituted aromatic systems.

Basic Information

Product Name	3,4,5-Trifluorobenzonitrile
CAS No.	134227-45-5
Molecular Formula	C7H2F3N
Molecular Weight	157.09 g/mol
Synonyms	3,4,5-Trifluorobenzene carbonitrile; Benzonitrile, 3,4,5-trifluoro-; 3,4,5-Trifluorophenyl cyanide; 3,4,5-Trifluorobenzonitrile; 134227-45-5; 3,4,5-Trifluorobenzonitrile (C7H2F3N); 3,4,5-Trifluoro-benzonitrile
EINECS	Contact for details

Quality Control

Our 3,4,5-Trifluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.