Description

Androsta-1,4-Diene-17-Carboxylic Acid, 17-[(Ethoxycarbonyl)Oxy]-11-Hydroxy-3-Oxo-, (11β,17α)- is a high-purity steroid derivative and a key advanced pharmaceutical intermediate (API) in the synthesis of potent glucocorticoid receptor modulators. Its precise molecular architecture is critical for developing next-generation anti-inflammatory and immunosuppressive therapeutics with targeted activity. This compound is essential for pharmaceutical R&D laboratories and manufacturers specializing in corticosteroid-based drug discovery and production, where consistent quality and reliable supply are paramount. The CAS number for this compound is 133991-63-6.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of novel glucocorticoid receptor agonists and antagonists.
• Anti-inflammatory Drug Development: Used in research and production of potent corticosteroid medications targeting conditions like asthma, dermatitis, and autoimmune disorders.
• Immunosuppressant Synthesis: Serves as a precursor for compounds used to prevent organ transplant rejection and treat severe allergic reactions.
• Steroid Chemistry Research: A valuable reference standard and starting material for academic and industrial research into steroid structure-activity relationships (SAR).
• Veterinary Pharmaceutical Manufacturing: Employed in the formulation of anti-inflammatory treatments for companion and livestock animals.
• Process Development & Scale-up: Used by process chemists to optimize synthetic routes for commercial-scale API manufacturing under GMP guidelines.

Basic Information

Product Name	Androsta-1,4-Diene-17-Carboxylic Acid, 17-[(Ethoxycarbonyl)Oxy]-11-Hydroxy-3-Oxo-, (11β,17α)-
CAS No.	133991-63-6
Molecular Formula	C23H30O7
Molecular Weight	418.48 g/mol
Synonyms	11β,17α-Dihydroxy-3-oxoandrosta-1,4-diene-17β-carboxylic acid γ-lactone 17-ethyl carbonate; (11β,17α)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic acid; 11β-Hydroxy Canrenone Ethyl Carbonate; SC-9376; Spirorenone Ethyl Carbonate; 17α-Hydroxy-3-oxopregna-1,4-diene-21-carboxylic Acid γ-Lactone 17-Ethyl Carbonate; Canrenone Derivative.
EINECS	Contact for details

Quality Control

Our Androsta-1,4-Diene-17-Carboxylic Acid derivative is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for pharmaceutical intermediates. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and conformance to agreed specifications. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant pharmacopeial guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Optical Rotation	Specific range provided on COA
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.