Description

2-Amino-3,5,6-trifluoroterephthalonitrile is a high-value, multi-fluorinated aromatic nitrile derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its molecular structure, featuring both amino and nitrile groups on a perfluorinated benzene ring, makes it a versatile precursor for constructing complex molecules with tailored electronic and physical properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, where it is used to develop novel active ingredients, as well as in materials science for creating specialty polymers and organic electronic components.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Serves as a precursor for developing next-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance bioavailability and environmental stability.
• Functional Material Precursor: Used in the research and production of advanced materials, including liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs) for sensing and catalysis.
• Dye and Pigment Chemistry: Intermediate for synthesizing specialized fluorinated dyes and pigments with unique light-fastness and color properties.
• Cross-Coupling Reactions: Valuable substrate in palladium-catalyzed cross-coupling reactions (e.g., Buchwald-Hartwig amination) to create complex biaryl and heteroaryl structures.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on fluoroorganic chemistry and the exploration of new chemical entities.

Basic Information

Item	Details
Product Name	2-Amino-3,5,6-Trifluoroterephthalonitrile
CAS No.	133622-66-9
Molecular Formula	C8H2F3N3
Molecular Weight	203.12 g/mol
Synonyms	2-Amino-3,5,6-trifluorobenzene-1,4-dicarbonitrile; 3,5,6-Trifluoro-2-aminoterephthalonitrile; 1,4-Dicyano-2-amino-3,5,6-trifluorobenzene; 2-Amino-3,5,6-trifluoro-1,4-benzenedicarbonitrile; Terephthalonitrile, 2-amino-3,5,6-trifluoro-; 2-Amino-3,5,6-trifluorophthalonitrile (common misnomer); 3,5,6-Trifluoro-2-aminobenzene-1,4-dicarbonitrile
EINECS	Contact for details

Quality Control

Our production of 2-Amino-3,5,6-trifluoroterephthalonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assay and identity confirmation via FT-IR and NMR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP standards for pharmaceutical applications and can tailor specifications to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.