Description

Landiolol is a highly selective, ultra-short-acting β-1 adrenergic receptor antagonist. This compound is of significant commercial and clinical importance due to its rapid onset and offset of action, making it a valuable agent for precise hemodynamic control. It is primarily required by pharmaceutical manufacturers and research institutions developing or producing injectable formulations for the management of intraoperative and perioperative tachycardia and hypertension.

Application

• Pharmaceutical Active Ingredient (API): Core component in the manufacture of injectable solutions for acute cardiac rate control.
• Cardiac Surgery: Used to manage tachycardia and hypertension during and after surgical procedures, including coronary artery bypass grafting (CABG).
• Non-Cardiac Surgery: Administration for hemodynamic stabilization in patients undergoing major operations.
• Critical Care Medicine: Management of supraventricular tachyarrhythmias in intensive care unit (ICU) settings.
• Clinical Research: Reference standard and active compound in pharmacokinetic, pharmacodynamic, and new formulation studies.
• Drug Development: Serves as a model compound for developing other ultra-short-acting cardiovascular agents.

Basic Information

Product Name	Landiolol
CAS No.	133242-30-5
Molecular Formula	C25H36N2O6S
Molecular Weight	492.63 g/mol
Synonyms	Landiolol Hydrochloride; ONO-1101; (2S)-2-{4-[(2S)-2-Hydroxy-3-{[2-(4-morpholinylcarbonyl)phenyl]thio}propyl]phenoxy}-N-(2-methoxyethyl)acetamide; 2-Propanamide, 2-[4-[(2-hydroxy-3-[[2-(4-morpholinylcarbonyl)phenyl]thio]propyl]phenoxy]-N-(2-methoxyethyl)-, (2S)-; ONO1101
EINECS	Contact for details

Quality Control

Our Landiolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles as per agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.