Description

2-Amino-3-Bromo-5-Trifluoromethyl-Benzonitrile is a high-value, multi-functional aromatic intermediate featuring amino, bromo, cyano, and trifluoromethyl substituents. This unique structure makes it a critical building block for synthesizing complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel active ingredients. The compound's versatility also extends to materials science for creating specialized polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a core scaffold for developing new herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl and bromo groups.
• Material Science Research: Used in the development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-withdrawing groups.
• Liquid Crystal & Dye Intermediate: Acts as a building block for creating novel liquid crystal compounds and high-performance dyes and pigments.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create more complex biaryl structures.
• Chemical Biology & Proteomics: Utilized as a versatile tag or linker molecule in probe development for studying biological systems and protein interactions.

Basic Information

Product Name	2-Amino-3-Bromo-5-Trifluoromethyl-Benzonitrile
CAS No.	133013-30-6
Molecular Formula	C8H4BrF3N2
Molecular Weight	265.03 g/mol
Synonyms	3-Bromo-2-amino-5-(trifluoromethyl)benzonitrile; 2-Amino-3-bromo-α,α,α-trifluoro-p-toluonitrile; Benzonitrile, 2-amino-3-bromo-5-(trifluoromethyl)-; 5-(Trifluoromethyl)-2-amino-3-bromobenzonitrile; 3-Bromo-2-cyano-6-(trifluoromethyl)aniline; 2-Amino-3-bromo-5-trifluoromethylbenzonitrile; 2-Cyano-6-trifluoromethyl-3-bromoaniline
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Bromo-5-Trifluoromethyl-Benzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent identity. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.