Description

2-Methoxy-4-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic nitrile building block distinguished by its methoxy and trifluoromethyl substituents. This compound is essential for advanced organic synthesis, offering a unique combination of electronic and steric properties that facilitate the development of novel chemical entities. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating active ingredients and intermediates with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group often improves lipophilicity and biological efficacy.
• Liquid Crystal & OLED Materials: Serves as a building block for advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its stable aromatic core and polarizable groups.
• Functional Dye & Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where the nitrile and methoxy groups contribute to color fastness and specific light-absorption properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to construct complex biaryl systems for material science and drug discovery.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D labs exploring new synthetic methodologies and novel compound libraries.

Basic Information

Product Name	2-Methoxy-4-(Trifluoromethyl)Benzonitrile
CAS No.	132927-08-3
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	4-(Trifluoromethyl)-2-methoxybenzonitrile; 2-Methoxy-α,α,α-trifluoro-p-tolunitrile; 4-Cyano-3-methoxybenzotrifluoride; 2-Methoxy-4-trifluoromethylbenzonitrile; p-(Trifluoromethyl)-o-methoxybenzonitrile; 2-Methoxy-4-(trifluoromethyl)phenyl cyanide; Benzonitrile, 2-methoxy-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 2-Methoxy-4-(Trifluoromethyl)Benzonitrile is manufactured and tested under a strict quality management system. We guarantee high purity and consistent batch-to-batch performance to meet the exacting standards of advanced synthetic applications. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.