Description

2-Bromo-1-Nitro-4-(Trifluoromethyl)Benzene is a high-purity halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromo, nitro, and trifluoromethyl substituents, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination, enabling the introduction of complex aryl groups.
• Fluorine Chemistry Research: A valuable reagent for studying structure-activity relationships (SAR) and the effects of fluorine substitution in molecular design.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments where halogen and nitro groups are integral to color and fastness properties.

Basic Information

Product Name	2-Bromo-1-Nitro-4-(Trifluoromethyl)Benzene
CAS No.	132839-58-8
Molecular Formula	C7H3BrF3NO2
Molecular Weight	269.99 g/mol
Synonyms	1-Bromo-2-nitro-4-(trifluoromethyl)benzene; 2-Bromo-α,α,α-trifluoro-p-nitrotoluene; 4-Bromo-3-nitrobenzotrifluoride; 2-Bromo-1-nitro-4-(trifluoromethyl)benzene; 2-Nitro-5-bromobenzotrifluoride; 5-Bromo-2-nitrobenzotrifluoride; 2-Bromo-α,α,α-trifluoro-4-nitrotoluene; Benzene, 2-bromo-1-nitro-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-Nitro-4-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature (store away from light), the container should be amber-colored or stored in a dark place. Keep the container tightly sealed when not in use to prevent contamination and moisture uptake.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.