Description

3'-Hydroxyesorubicin is a chemically modified derivative of the anthracycline antibiotic, doxorubicin. This compound is a critical pharmaceutical intermediate and a valuable reference standard in the research and development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on oncology drug discovery and analytical method development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced anthracycline-based anticancer drugs.
• Reference Standard: Used for analytical method development, validation, and quality control (QC/QA) in pharmaceutical manufacturing.
• Biochemical Research: Employed in studies investigating the structure-activity relationships (SAR) of anthracycline antibiotics to understand mechanisms of action and reduce cardiotoxicity.
• Metabolite Studies: Serves as a reference compound for the identification and quantification of drug metabolites in pharmacokinetic and pharmacodynamic research.
• Academic Research: Utilized in university and institutional labs for fundamental research in medicinal chemistry and oncology.

Basic Information

Product Name	3'-Hydroxyesorubicin
CAS No.	130592-19-7
Molecular Formula	C27H29NO11
Molecular Weight	543.52 g/mol
Synonyms	3'-Hydroxydoxorubicin; 3'-Hydroxy-14-hydroxydaunorubicin; 3'-OH-Doxorubicin; 3'-Hydroxyadriamycin; 3'-Hydroxy-14-hydroxydaunomycin; Esorubicin 3'-hydroxy derivative; (8S,10S)-10-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-3'-hydroxy-1-methoxy-5,12-naphthacenedione
EINECS	Contact for details

Quality Control

Our 3'-Hydroxyesorubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.