Description

Poly-4-Vinylpyridinium Poly(Hydrogen Fluoride) is a polymeric reagent that combines the properties of a solid-supported base with a source of fluoride ions. This compound matters for its unique ability to act as a versatile and safer alternative to hazardous anhydrous hydrogen fluoride (HF) in various synthetic transformations. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for demanding fluorination and deprotection reactions.

Application

• Nucleophilic Fluorination Reactions: A key reagent for the introduction of fluorine atoms into organic molecules under milder and safer conditions than traditional methods.
• Selective Deprotection Agent: Used for the cleavage of silicon-based protecting groups (e.g., TBDMS, TIPS) in complex multi-step syntheses, particularly in oligonucleotide and peptide chemistry.
• Solid-Phase Synthesis Support: Functions as a polymeric reagent in combinatorial chemistry and solid-phase organic synthesis (SPOS) for parallel library generation.
• Catalyst and Promoter: Acts as a promoter or catalyst in various organic transformations requiring a source of fluoride ion and a basic environment.
• Research & Development: An essential tool in medicinal chemistry for creating fluorinated analogs of lead compounds to modulate their bioavailability and metabolic stability.
• Fine Chemical Manufacturing: Employed in the scaled-up production of fluorinated intermediates for agrochemicals, pharmaceuticals, and advanced materials.

Basic Information

Product Name	Poly-4-Vinylpyridinium Poly(Hydrogen Fluoride)
CAS No.	130495-33-9
Molecular Formula	(C7H7N·(HF)x)n
Molecular Weight	Variable (Polymer)
Synonyms	Poly(4-vinylpyridinium) poly(hydrogen fluoride); PVP-HF; Polyvinylpyridinium Poly(Hydrogen Fluoride); Poly(4-Vinylpyridine) Hydrofluoride; 4-Ethenylpyridine Homopolymer Hydrofluoride; Poly(4-Vinylpyridine) HF Complex; Solid-Supported HF Reagent; Polymeric Hydrogen Fluoride Reagent
EINECS	Contact for details

Quality Control

Our Poly-4-Vinylpyridinium Poly(Hydrogen Fluoride) is manufactured under controlled conditions to ensure batch-to-batch consistency and high performance. Each lot undergoes rigorous quality testing, including assay for active fluoride content and characterization of polymer properties. A comprehensive Certificate of Analysis (COA) detailing purity, physical form, and safety data is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain reactivity.

Specification

Item	Specification
Appearance	Off-white to pale yellow solid
Identification (IR)	Conforms to structure
Assay (Fluoride Content)	30 - 40% (w/w)
Water Content (KF)	≤ 2.0 %
Particle Size (Mesh)	20 - 100

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.