Description

2,6-Dichloro-1-Fluoropyridinium Triflate is a highly reactive and versatile fluorination reagent and electrophilic fluorinating agent. It is particularly valued for its ability to introduce fluorine atoms into complex organic molecules under mild conditions, a critical transformation in modern pharmaceutical and agrochemical development. This compound is essential for research chemists and process development scientists working in medicinal chemistry, material science, and the synthesis of advanced intermediates.

Application

• Electrophilic Fluorination: A key reagent for the selective introduction of fluorine into electron-rich aromatic and heteroaromatic systems, enabling late-stage functionalization in drug discovery.
• Pharmaceutical Intermediate Synthesis: Used in the production of active pharmaceutical ingredients (APIs) containing fluorine, which can improve metabolic stability, bioavailability, and binding affinity.
• Agrochemical Development: Employed in the synthesis of novel herbicides, pesticides, and fungicides where fluorinated compounds often exhibit enhanced activity and environmental persistence.
• Material Science Research: Facilitates the creation of fluorinated organic materials, such as liquid crystals, polymers, and electronic chemicals, with unique properties.
• Radiochemistry: Serves as a precursor or model compound in the development of 18F-labeled positron emission tomography (PET) tracers for medical imaging.
• Cross-Coupling Reactions: Can act as an activating agent or intermediate in palladium-catalyzed cross-coupling reactions to build complex molecular architectures.

Basic Information

Product Name	2,6-Dichloro-1-Fluoropyridinium Triflate
CAS No.	130433-68-0
Molecular Formula	C7H3Cl2F4NO3S
Molecular Weight	328.07 g/mol
Synonyms	1-Fluoro-2,6-dichloropyridinium Trifluoromethanesulfonate; 2,6-Dichloro-1-fluoropyridin-1-ium Triflate; 2,6-Dichloro-1-fluoropyridinium Trifluoromethanesulfonate; N-Fluoro-2,6-dichloropyridinium Triflate; Selectfluor™ B (Analog); Electrophilic Fluorinating Reagent; 1-Fluoro-2,6-dichloropyridinium Salt
EINECS	Contact for details

Quality Control

Our 2,6-Dichloro-1-Fluoropyridinium Triflate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We adhere to cGMP principles where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.