Description

δ-9(11)-Fluorometholone Acetate is a high-purity synthetic steroid derivative, specifically a fluorinated glucocorticoid ester. This compound is a critical advanced intermediate in the pharmaceutical synthesis of potent topical corticosteroids. It is primarily sought by research and development laboratories and active pharmaceutical ingredient (API) manufacturers for the production of specialized anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of fluorinated corticosteroid APIs like Fluorometholone.
• Ophthalmic Drug Development: Used in R&D for creating steroid formulations targeting eye inflammation and post-surgical care.
• Dermatological Research: Serves as a precursor in developing topical creams and ointments for treating skin conditions such as eczema, psoriasis, and dermatitis.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes and scaling production for commercial pharmaceutical manufacturing.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor activity and metabolic pathways.

Basic Information

Item	Details
Product Name	δ-9(11)-Fluorometholone Acetate
CAS No.	130145-14-1
Molecular Formula	C₂₄H₃₁FO₆
Molecular Weight	434.50 g/mol
Synonyms	9,11β-Epoxy-6α-fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-Acetate; 9β,11β-Epoxy-6α-fluoro-16α-methylprednisolone 21-Acetate; Fluorometholone Acetate Impurity; (6α,11β,16α)-9,11-Epoxy-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 21-Acetate; δ⁹⁽¹¹⁾-Fluorometholone Acetate
EINECS	Contact for details

Quality Control

Our δ-9(11)-Fluorometholone Acetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.