Description

Levocetirizine Dihydrochloride CAS NO 130018-87-0 is the active pharmaceutical ingredient (API) of the R-enantiomer of cetirizine, a potent and highly selective third-generation H1-receptor antagonist. This compound is valued for its enhanced efficacy and reduced sedative effects compared to the racemic mixture, making it a critical component in modern antihistamine therapies. It is primarily required by pharmaceutical manufacturers for the production of prescription and over-the-counter (OTC) medications targeting allergic conditions such as rhinitis, chronic urticaria, and allergic conjunctivitis.

Application

• Pharmaceutical API: Primary use as the active ingredient in solid oral dosage forms (tablets, capsules) and oral solutions for systemic allergy relief.
• Antihistamine Formulations: Manufacture of prescription and OTC medications for the treatment of seasonal and perennial allergic rhinitis.
• Chronic Idiopathic Urticaria Treatment: Key component in drugs designed to alleviate symptoms of chronic hives and skin allergies.
• Allergic Conjunctivitis Medications: Used in formulations targeting eye allergy symptoms.
• Pediatric Allergy Solutions: Incorporated into age-appropriate, lower-dose formulations for children.
• Research & Development: Serves as a high-purity reference standard and starting material for novel drug development and pharmacokinetic studies.

Basic Information

Product Name	Levocetirizine Dihydrochloride
CAS No.	130018-87-0
Molecular Formula	C21H27Cl3N2O3
Molecular Weight	461.81 g/mol
Synonyms	(R)-Cetirizine Dihydrochloride; Levocetirizine HCl; (2-[4-[(R)-(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy)acetic acid dihydrochloride; XYZAL® (Brand Name API); R-Cetirizine Dihydrochloride; Allercet; Vozet; Alercet
EINECS	Contact for details

Quality Control

Our Levocetirizine Dihydrochloride is manufactured under strict quality management systems. We ensure compliance with major pharmacopoeial standards, including USP and EP monographs. Every batch undergoes rigorous analytical testing for identity, purity, and impurities. A comprehensive Certificate of Analysis (COA) detailing all test results is provided to guarantee the material meets your specific application requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities: NMT 1.0% Any individual impurity: NMT 0.5%
Optical Rotation	Contact for details
Water Content (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.