Description

(S)-Cetirizine is the pharmacologically active enantiomer of the widely used second-generation antihistamine, cetirizine dihydrochloride. This high-purity chiral intermediate is critical for the development of enantiomerically pure pharmaceuticals, offering superior specificity and potentially reduced side-effect profiles compared to racemic mixtures. It is an essential building block for advanced pharmaceutical manufacturers and R&D laboratories focused on next-generation allergy and inflammation treatments.

Application

• Active Pharmaceutical Ingredient (API) for enantiomerically pure antihistamine medications.
• Key chiral intermediate in the synthesis of levocetirizine and related advanced therapeutics.
• Reference standard for analytical method development and quality control in pharmaceutical labs.
• Starting material for research into novel H1-receptor antagonists with improved efficacy.
• Critical component in the development of fixed-dose combination drugs for allergic conditions.
• Used in preclinical and clinical studies to investigate the pharmacokinetics of the (S)-enantiomer.

Basic Information

Product Name	(S)-Cetirizine
CAS No.	130018-76-7
Molecular Formula	C21H25ClN2O3
Molecular Weight	388.89 g/mol
Synonyms	Levocetirizine Impurity; (-)-Cetirizine; (S)-(-)-2-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid; (S)-[2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic Acid; UNII-6U5EA9RT2O; (S)-Cetirizine Free Base
EINECS	Contact for details

Quality Control

Our (S)-Cetirizine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5%
Single Maximum Unknown Impurity	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.