Description

Dynemicin H is a potent enediyne antitumor antibiotic compound, notable for its unique molecular architecture and mechanism of action. This compound is of significant interest in advanced pharmaceutical research and development due to its ability to cleave DNA through a Bergman cycloaromatization process. It serves as a critical reference standard and a key intermediate for researchers in oncology, medicinal chemistry, and molecular biology, enabling the study of novel cancer therapeutics and DNA-protein interactions.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical method development, validation, and quality control in drug discovery and development.
• Oncology Research: Serves as a crucial tool compound for investigating the mechanisms of enediyne antibiotics, DNA damage, and apoptosis in cancer cell lines.
• Medicinal Chemistry Studies: Employed as a lead compound or synthetic intermediate for the design and synthesis of novel antitumor agents with improved efficacy and reduced toxicity.
• Biochemical Research: Utilized in studies exploring DNA-protein interactions, chromatin dynamics, and the cellular response to DNA double-strand breaks.
• Academic and Institutional Research: A vital reagent for universities and research institutes focusing on chemical biology, natural product synthesis, and anticancer drug mechanisms.

Basic Information

Product Name	Dynemicin H
CAS No.	129985-03-1
Molecular Formula	C30H22N2O8
Molecular Weight	538.51 g/mol
Synonyms	Dynemicin H; Antibiotic Dynemicin H; 5,11-Dideoxydynemicin A; 1,5-Diyn-3-ene-1,2,5,11-tetradeoxy-11-[(10S)-10-ethyl-9,10-dihydro-9-oxo-7H-pyrido[4,3,2-kl]acridin-7-yl]-L-erythro-α-D-galacto-undecopyranosid-4-ulo se; (1S,2R,3S,4S,5R,6R,7R,8R,9R,10S,11S)-2,3,4,5,6,7,8,9,10,11-Decahydro-10-ethyl-2,3,4,5,6,7,8,9,11-dehydroxy-1-[[(10S)-10-ethyl-9,10-dihydro-9-oxo-7H-pyrido[4,3,2-kl]acridin-7-yl]oxy]undecopyranosid-4-ulo se
EINECS	Contact for details

Quality Control

Our Dynemicin H is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, generated using validated analytical methods such as HPLC, NMR, and MS. We are committed to supplying materials that meet the exacting standards required for pharmaceutical and biochemical research.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.