Description

2,5-Difluoro-4-(hydrazino)-benzonitrile is a high-value, multi-functional aromatic intermediate featuring both a hydrazine and a nitrile group on a difluorinated benzene ring. This unique structure makes it a critical building block for synthesizing complex heterocyclic compounds, particularly in advanced pharmaceutical and agrochemical research. It is essential for medicinal chemists and process development scientists working on novel active ingredients, where its reactive handles enable the construction of pyrazole, triazole, and other nitrogen-containing scaffolds. The compound's precise synthesis and high purity are paramount for ensuring the success and reproducibility of downstream chemical transformations.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of fluorinated heterocycles.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Industry: Employed in the creation of specialized fluorinated dyes and colorants with enhanced stability and performance properties.
• Chemical Biology & Proteomics: Acts as a reactive handle in bioconjugation chemistry for labeling biomolecules or creating chemical probes.
• Academic & Contract Research: A valuable reagent for methodology development and exploratory synthesis in university and CRO laboratories worldwide.

Basic Information

Product Name	2,5-Difluoro-4-(hydrazino)-benzonitrile
CAS No.	129946-63-0
Molecular Formula	C7H5F2N3
Molecular Weight	169.13 g/mol
Synonyms	4-Hydrazinyl-2,5-difluorobenzonitrile; 2,5-Difluoro-4-hydrazinylbenzonitrile; Benzonitrile, 2,5-difluoro-4-hydrazinyl-; 129946-63-0; 2,5-Difluoro-4-hydrozinylbenzonitrile; 4-Hydrazino-2,5-difluorobenzonitrile; AKOS005258065; FT-0696667
EINECS	Contact for details

Quality Control

Every batch of 2,5-Difluoro-4-(hydrazino)-benzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as identity (IR, NMR), purity (HPLC), and impurity profile. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.