Description

3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic intermediate characterized by its unique halogenated and nitrile-substituted structure. This compound is critical for introducing specific steric and electronic properties into target molecules, enabling the synthesis of advanced materials and active pharmaceutical ingredients. It is primarily sought after by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl and halogen groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for creating specialized fluorinated components used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D for exploring new reactions and creating libraries of fluorinated compounds for screening.
• Dye & Pigment Intermediate: Used in the synthesis of specialized, high-performance dyes and pigments that require halogen and nitrile functional groups for color fastness and specific hues.

Basic Information

Product Name	3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzonitrile
CAS No.	129931-47-1
Molecular Formula	C8H2ClF4N
Molecular Weight	223.56 g/mol
Synonyms	2-Fluoro-3-chloro-5-(trifluoromethyl)benzonitrile; 5-(Trifluoromethyl)-3-chloro-2-fluorobenzonitrile; 3-Chloro-2-fluoro-α,α,α-trifluoro-p-tolunitrile; 2-Fluoro-3-chloro-α,α,α-trifluoro-p-tolunitrile; Benzonitrile, 3-chloro-2-fluoro-5-(trifluoromethyl)-; 129931-47-1; 3-Chloro-2-fluoro-5-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-2-Fluoro-5-(Trifluoromethyl)Benzonitrile adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Every lot is fully characterized and undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.