Description

2-Chloro-6-(Trifluoromethyl)Benzonitrile is a versatile and high-value aromatic nitrile building block distinguished by its trifluoromethyl and chloro substituents. This compound is critical for introducing the trifluoromethyl group, a key pharmacophore known to enhance metabolic stability, lipophilicity, and bioavailability in active molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves efficacy and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its aromatic core and electron-withdrawing groups.
• Chemical Biology & Proteomics: Employed as a building block for designing chemical probes and activity-based protein profiling (ABPP) agents.
• Custom Synthesis & Contract Manufacturing: A high-purity starting material for custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	2-Chloro-6-(Trifluoromethyl)Benzonitrile
CAS No.	129604-28-0
Molecular Formula	C8H3ClF3N
Molecular Weight	205.56 g/mol
Synonyms	2-Chloro-α,α,α-trifluoro-o-tolunitrile; 2-Chloro-6-(trifluoromethyl)benzenecarbonitrile; 6-Chloro-2-(trifluoromethyl)benzonitrile; 2-Chloro-α,α,α-trifluoro-2-methylbenzonitrile; o-Chloro-α,α,α-trifluorotolunitrile; 2-Chloro-6-trifluoromethylbenzonitrile; 2-Chloro-α,α,α-trifluoro-o-toluonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-6-(Trifluoromethyl)Benzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments, supporting regulatory filings and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage under an inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.