Description

3-Chloro-4-(Trifluoromethoxy)Benzonitrile is a high-value, multi-functional aromatic intermediate featuring both chloro and trifluoromethoxy substituents on a benzonitrile core. This compound matters for its role as a critical building block in the synthesis of advanced agrochemicals and pharmaceuticals, where its unique halogenated structure imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the agrochemical, pharmaceutical, and specialty chemical industries seeking to develop new active ingredients and functional materials.

Application

• Agrochemical Intermediate: A key synthon for the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethoxy and chloro groups.
• Pharmaceutical Building Block: Used in medicinal chemistry for the synthesis of drug candidates, particularly in central nervous system (CNS) and anti-inflammatory target areas.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for the synthesis of fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: The chloro group is amenable to palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for creating complex biaryl structures.
• Cyanohydrin & Amide Synthesis: The nitrile functionality can be hydrolyzed to carboxylic acids or reduced to amines for further derivatization.

Basic Information

Product Name	3-Chloro-4-(Trifluoromethoxy)Benzonitrile
CAS No.	129604-26-8
Molecular Formula	C8H3ClF3NO
Molecular Weight	221.56 g/mol
Synonyms	3-Chloro-4-(trifluoromethoxy)benzonitrile; 4-Cyano-2-chloro-1-(trifluoromethoxy)benzene; 2-Chloro-α,α,α-trifluoro-p-cyanomethoxybenzene; 3-Chloro-4-trifluoromethoxybenzonitrile; Benzonitrile, 3-chloro-4-(trifluoromethoxy)-; 3-Chloro-4-(trifluoromethoxy)phenyl cyanide
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with global regulatory frameworks, including REACH.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.