Description

3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-β-D-Arabinocytidine is a key fluorinated nucleoside derivative and a critical protected intermediate in the synthesis of advanced pharmaceutical compounds. Its primary value lies in enabling the precise construction of modified nucleic acid analogs, which are essential for developing targeted antiviral and anticancer therapeutics. This high-purity building block is indispensable for research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of novel nucleoside-based drugs and prodrugs.

Application

• Pharmaceutical Intermediate: A vital precursor in the multi-step synthesis of fluorinated cytidine analogs and related active pharmaceutical ingredients (APIs).
• Antiviral Drug Research: Used in the development of novel nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents targeting viruses like hepatitis B (HBV) and human immunodeficiency virus (HIV).
• Anticancer Agent Development: Serves as a building block for creating chemotherapeutic prodrugs that interfere with cancer cell DNA/RNA synthesis.
• Prodrug Synthesis: The benzoyl protecting groups facilitate specific chemical modifications, making it ideal for creating prodrugs with enhanced bioavailability and targeted delivery.
• Biochemical Research: Employed in academic and industrial R&D for studying enzyme mechanisms, nucleic acid chemistry, and structure-activity relationships (SAR).
• Process Chemistry & Scale-up: Suitable for use in process development and optimization for the commercial-scale manufacturing of fluorinated nucleosides.

Basic Information

Product Name	3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-β-D-Arabinocytidine
CAS No.	128495-99-8
Molecular Formula	C23H20FN3O6
Molecular Weight	453.42 g/mol
Synonyms	2'-Deoxy-2'-fluoro-3',5'-di-O-benzoyl-β-D-arabinocytidine; 2'-Fluoro-2'-deoxy-3',5'-di-O-benzoyl-β-D-arabinocytidine; 3',5'-Di-O-benzoyl-2'-deoxy-2'-fluoro-β-D-arabinocytidine; 2'-F-ara-C 3',5'-Dibenzoate; Fluorinated Cytidine Intermediate; Benzoylated 2'-F-Arabinocytidine; NSC 382501 (related catalog number)
EINECS	Contact for details

Quality Control

Our 3',5'-Di-o-Benzoyl-2'-Deoxy-2'-Fluoro-β-D-Arabinocytidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, supporting its use in advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled with care to avoid exposure to strong alkalis or fluorides. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Single Maximum Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.