Description

Altromycin A is a potent ansamycin-class antibiotic compound with significant biological activity. Its primary value lies in its role as a critical research tool for studying RNA polymerase inhibition and as a lead compound in the development of novel anti-infective and anti-cancer agents. This high-purity chemical is essential for pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on microbiology, oncology, and molecular biology.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery of new antibacterial and antitumor drugs.
• Biochemical Mechanism Studies: Used extensively in vitro to investigate the inhibition of bacterial DNA-dependent RNA polymerase, providing insights into transcription processes.
• Microbiology & Antibiotic Research: Employed as a potent tool compound to study bacterial resistance mechanisms and to evaluate the efficacy of new antibiotic candidates.
• Oncology Research: Investigated for its cytotoxic properties and potential application in cancer cell line studies and preclinical models.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in molecular biology and medicinal chemistry.
• Biotech Catalyst: Utilized in high-throughput screening assays to identify new biological targets and therapeutic pathways.

Basic Information

Product Name	Altromycin A
CAS No.	128439-47-4
Molecular Formula	C₃₉H₄₇NO₁₄
Molecular Weight	753.79 g/mol
Synonyms	BMY-28438; U-73975; Antibiotic BMY 28438; Ansamycin BMY 28438; (2S,4aR,6R,7S,8S,9S,11aR,11bS)-11b-[(2R,5S,6S)-5-(Dimethylamino)-6-methyloxan-2-yl]-2,4a,6,7,8,9,11a,11b-octahydro-7,8,9-trihydroxy-6-methoxy-2-methyl-7,11b-epoxynaphtho[2,1-b]oxepin-5,10-dione; Altromycin
EINECS	Contact for details

Quality Control

Our Altromycin A is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with our rigorous in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be kept in a dry, well-ventilated area. Allow the product to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.