Description

4-(Pentafluoroethyl)Benzonitrile is a high-value fluorinated aromatic intermediate featuring a pentafluoroethyl group attached to a benzonitrile core. This compound matters for its unique combination of aromatic stability, fluorine's electron-withdrawing properties, and the versatile reactivity of the nitrile group, making it a critical building block for advanced material synthesis. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty polymer industries seeking to develop novel compounds with enhanced metabolic stability, lipophilicity, or specific electronic characteristics.

Application

• Pharmaceutical Intermediate: Serves as a key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic moieties to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the pentafluoroethyl group can enhance biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated liquid crystal compounds and electron-transport materials in organic light-emitting diodes (OLEDs) due to its influence on molecular polarity and packing.
• Polymer & Resin Modifier: Incorporated into specialty polymers to impart unique properties such as chemical resistance, low surface energy, and improved thermal stability.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, cyano group transformations, and as a scaffold for constructing complex fluorinated molecules in medicinal and material chemistry.

Basic Information

Product Name	4-(Pentafluoroethyl)Benzonitrile
CAS No.	128273-61-0
Molecular Formula	C9H4F5N
Molecular Weight	221.13 g/mol
Synonyms	p-(Pentafluoroethyl)benzonitrile; 4-(Pentafluoroethyl)benzonitrile; 4-(1,1,2,2,2-Pentafluoroethyl)benzonitrile; Benzonitrile, 4-(pentafluoroethyl)-; 1-Cyano-4-(pentafluoroethyl)benzene; 4-Cyanopentafluorotoluene; α,α,α,α',α'-Pentafluoro-p-tolunitrile
EINECS	Contact for details

Quality Control

Our 4-(Pentafluoroethyl)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.