Description

4,5-Difluoro-2-Nitrotoluene is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of fluorine and nitro substituents on the toluene backbone, which enables precise structural modifications for creating high-performance molecules. This compound is primarily sought by R&D chemists and process engineers in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, and electronic materials requiring fluorinated aromatic units.
• Dye and Pigment Intermediate: Employed in the synthesis of novel fluorinated dyes and colorants with improved lightfastness and chemical resistance.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl structures.
• Nitro Group Reduction: The nitro functionality provides a handle for reduction to corresponding amines, a common step in heterocycle and aniline derivative synthesis.

Basic Information

Product Name	4,5-Difluoro-2-Nitrotoluene
CAS No.	127371-50-0
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2-Nitro-4,5-difluorotoluene; 1,2-Difluoro-4-methyl-5-nitrobenzene; 4,5-Difluoro-2-nitrotoluene; 4-Methyl-3,6-difluoronitrobenzene; Toluene, 4,5-difluoro-2-nitro-; 5-Nitro-3,4-difluorotoluene
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Nitrotoluene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for fine chemical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.