Description

14-Chlorocarubicin is a synthetic anthracycline derivative, a class of compounds renowned for their potent biological activity. This compound serves as a critical pharmaceutical intermediate and a valuable research chemical for the development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on oncology.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced anthracycline-based anticancer drugs.
• Biochemical Research: Used in studies investigating structure-activity relationships (SAR) of anthracyclines to enhance efficacy and reduce cardiotoxicity.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Mechanistic Studies: Employed in preclinical research to explore DNA intercalation mechanisms and topoisomerase II inhibition.
• Analog Development: A starting point for the chemical modification and development of new analogs with improved pharmacological profiles.

Basic Information

Product Name	14-Chlorocarubicin
CAS No.	126722-64-3
Molecular Formula	C26H27ClNO10
Molecular Weight	548.95 g/mol
Synonyms	14-Chloro-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione; 14-Chloro-13-deoxydoxorubicin; 14-Chloro-13-deoxydaunorubicin; 14-Chloro-13-dihydrodaunorubicin; 14-Chlorodaunomycinone; AD 143; NSC 635991
EINECS	Contact for details

Quality Control

Our 14-Chlorocarubicin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and pharmaceutical synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.