Description

2,3-Difluoro-4-Hydroxybenzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both a nitrile group and hydroxyl substituent on a difluorinated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients. Its utility extends to materials science for developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics where the difluoro-hydroxybenzonitrile scaffold is valuable.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for high-performance displays (LCDs) due to its polarizable structure and stability.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers, including high-temperature resins and materials with specific dielectric properties.
• Organic Synthesis Reagent: A versatile reagent for constructing complex aromatic systems via reactions such as nucleophilic aromatic substitution (SNAr) and cyano group transformations.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic pathways and creating novel fluorinated compounds for various applications.

Basic Information

Product Name	2,3-Difluoro-4-Hydroxybenzonitrile
CAS No.	126162-38-7
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	4-Hydroxy-2,3-difluorobenzonitrile; 2,3-Difluoro-4-hydroxybenzenecarbonitrile; 2,3-Difluoro-4-cyanophenol; Benzonitrile, 2,3-difluoro-4-hydroxy-; 4-Cyano-2,3-difluorophenol
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-4-Hydroxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.