Description

Methyl (2S,4R)-4-Fluoroprolinate is a high-purity, non-natural amino acid derivative characterized by its specific stereochemistry at the 2 and 4 positions. This compound is a critical chiral building block in modern pharmaceutical synthesis, enabling the development of novel therapeutics with enhanced biological activity and metabolic stability. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of peptide-based drugs, enzyme inhibitors, and other bioactive molecules where precise stereochemical control is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in protease inhibitor and peptidomimetic drug discovery.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to incorporate a fluorinated proline analog, which can significantly alter peptide conformation, stability, and bioavailability.
• Medicinal Chemistry Research: Serves as a valuable scaffold for structure-activity relationship (SAR) studies to explore the impact of fluorination on drug potency and selectivity.
• Bioconjugation: Can be utilized in the preparation of labeled peptides or protein conjugates for diagnostic or research purposes.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes to study enzyme mechanisms and protein-protein interactions.

Basic Information

Product Name	Methyl (2S,4R)-4-Fluoroprolinate
CAS No.	126111-11-3
Molecular Formula	C6H10FNO2
Molecular Weight	147.15 g/mol
Synonyms	Methyl (2S,4R)-4-fluoropyrrolidine-2-carboxylate; (2S,4R)-4-Fluoroproline methyl ester; L-4-Fluoroproline methyl ester (specifying (2S,4R)); Methyl 4-fluoro-L-prolinate; 4-Fluoro-L-proline methyl ester; (4R)-4-Fluoro-L-proline methyl ester; 126111-11-3; Methyl (4R)-fluoro-L-prolinate
EINECS	Contact for details

Quality Control

Our Methyl (2S,4R)-4-Fluoroprolinate is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and standard identity/purity assays. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.